Neuroscience News (@NeuroscienceNew) posted at 6:35 pm on Fri, Oct 18, 2024:
Disrupted Protein Clearance After TBI Tied to Alzheimer’s
Researchers have discovered a biological link between traumatic brain injury (TBI) and Alzheimer’s disease, identifying how TBI increases the risk of Alzheimer’s through disrupted protein clearance.
The study found that
https://t.co/rDGjmz7F9r
(https://x.com/NeuroscienceNew/status/1847330801278484599?t=RpXGS5zpR_lb8KevObOfDA&s=03)
Neuroscience News
@NeuroscienceNew
Disrupted Protein Clearance After TBI Tied to Alzheimer’s Researchers have discovered a biological link between traumatic brain injury (TBI) and Alzheimer’s disease, identifying how TBI increases the risk of Alzheimer’s through disrupted protein clearance. The study found that TBI downregulates a key protein called BAG3, which is responsible for clearing damaged proteins in the brain. This leads to the accumulation of hyperphosphorylated tau, a hallmark of Alzheimer’s disease, in neurons. Using mouse models, the researchers showed that overexpressing BAG3 reduced tau buildup and improved cognitive function, highlighting its therapeutic potential. These findings suggest that targeting BAG3 could help prevent or mitigate Alzheimer’s pathology following TBI. The research opens new possibilities for developing treatments that reduce the risk of Alzheimer’s in individuals with a history of TBI.
About michelleclarke2015
Life event that changes all: Horse riding accident in Zimbabwe in 1993, a fractured skull et al including bipolar anxiety, chronic fatigue …. co-morbidities (Nietzche 'He who has the reason why can deal with any how' details my health history from 1993 to date). 17th 2017 August operation for breast cancer (no indications just an appointment came from BreastCheck through the Post). Trinity College Dublin Business Economics and Social Studies (but no degree) 1997-2003; UCD 1997/1998 night classes) essays, projects, writings. Trinity Horizon Programme 1997/98 (Centre for Women Studies Trinity College Dublin/St. Patrick's Foundation (Professor McKeon) EU Horizon funded: research study of 15 women (I was one of this group and it became the cornerstone of my journey to now 2017) over 9 mth period diagnosed with depression and their reintegration into society, with special emphasis on work, arts, further education; Notes from time at Trinity Horizon Project 1997/98; Articles written for Irishhealth.com 2003/2004; St Patricks Foundation monthly lecture notes for a specific period in time; Selection of Poetry including poems written by people I know; Quotations 1998-2017; other writings mainly with theme of social justice under the heading Citizen Journalism Ireland. Letters written to friends about life in Zimbabwe; Family history including Michael Comyn KC, my grandfather, my grandmother's family, the O'Donnellan ffrench Blake-Forsters; Moral wrong: An acrimonious divorce but the real injustice was the Catholic Church granting an annulment – you can read it and make your own judgment, I have mine. Topics I have written about include annual Brain Awareness week, Mashonaland Irish Associataion in Zimbabwe, Suicide (a life sentence to those left behind); Nostalgia: Tara Hill, Co. Meath.
canisgallicus 