Health

Bolstering our sense of smell may reduce the risk of dementia

Scientists are studying how a decline in our olfactory abilities can signal conditions such as Alzheimer’s

Nicola Davis Science correspondent

@NicolaKSDavisMon 25 Dec 2023 10.50 CET

Whether it is the waft of clove-studded oranges or the crisp fragrance of a fir tree, the festive season is filled with aromas that conjure Christmases past. Now researchers say our sense of smell, and its connection to our memory, could be used to help fight dementia.

Our senses can worsen as a result of disease and old age. But while impairment to hearing or vision is quickly apparent, a decline in our sense of smell can be insidious, with months or even years passing before it becomes obvious.

“Although it can have other causes, losing your sense of smell can be an early sign of dementia,” said Dr Leah Mursaleen, the head of research at Alzheimer’s Research UK, adding it was a potential indicator of damage in the olfactory region of the brain – that is, the part of the brain responsible for smell.

That has led to researchers examining whether loss of smell could be used to diagnose conditions such as Alzheimer’s long before symptoms such as memory loss set in – an approach, experts say, that could allow patients access to drugs such as lecanemab early in the course of the disease, when they work best to slow cognitive decline.

But just as research has suggested the use of hearing aids could reduce the risk of developing dementia, questions are being asked about whether bolstering our sense of smell could do the same. Could a declining sense of smell be a risk factor for cognitive decline, not just a symptom?

“Olfaction is intimately involved in many brain processes, and especially the emotional processing of stimuli,” said Prof Thomas Hummel, of Technische Universität Dresden. Indeed, smells, memories and emotions are often tightly bound, with research revealing recollections triggered by scent tend to be rooted in our childhood.

“If olfactory function fails, stimuli lose salience, which may affect general cognitive functions,” said Hummel.

Neurons involved in the olfactory system are also involved in other systems in the brain. Indeed, as Hummel and others note, some areas of the brain play a key role in cognitive and olfactory processes. As a result, if the sense of smell becomes dysfunctional, cognitive processing might also be affected.

A number of studies have found that exposure to certain odours can either boost or hinder cognition, while work by Hummel and colleagues has suggested smell training in older people can improve their verbal function and subjective wellbeing.

More pertinent still, a small study published last year, by researchers in Korea, revealed that intensive smell training led to improvements in depression, attention, memory and language functions in 34 patients with dementia compared with 31 participants with dementia who did not retrieve such training.

“We’ve already seen some early studies suggesting that ‘training’ our sense of smell, through repeated exposure to strong-smelling substances, could have benefits in improving cognitive performance in certain tasks,” said Mursaleen.

“However, much more research is needed to understand whether things like olfactory training could help prevent or slow down the onset and progression of mild cognitive impairment and dementia.”

Among other problems, intensive scent training takes time and effort. In an attempt to solve this problem, Dr Michael Leon, professor emeritus at the University of California, Irvine, and his team have come up with a device called “Memory Air that emits 40 different smells twice a night, while people are sleeping – an approach Leon says allows “universal compliance”. The hope is that exposing people to more smells, even when they are asleep, could strengthen their olfactory abilities.